Liste des séminaires
Demystifying Machine and Deep Learning and overview of their applications in biologyArtificial Intelligence is a broad term that is often misunderstood. Its subfields, such as machine and deep learning have achieved astonishing performances, such as some Large Language Models passing the Turing Test or AlphaFold offering a solution to a 50 years old problem. Because new technolo... |
THE GENERATION OF NEURONAL DIVERSITY AND ITS EVOLUTIONClaude Desplan1,2, Nikos Konstantinides1, Felix Simon1, Neset Ozel1, Isabel Holguera1, Jennifer Malin1, Yen Chen1, and Bogdan Sieriebriennikov1 1 Center for Developmental Genetics, Department of Biology, New York University, New York, USA; 2 Center for Genomics and System Biology, NYU Abu... |
Common threads in regeneration: mechano-chemical insights from a jellyfish modelHow randomly injured animals can appropriately re-establish positional information and control the deployment of repair programs are key questions of regenerative biology. The hydrozoan jellyfish Clytia hemisphaerica has recently emerged as an original model organism for probing repair phenomena,... |
Understanding and modeling agingAging is associated with a decline in tissue function and the onset of a constellation of diseases. We are interested in understanding aging, with a particular focus on brain aging. Because aging is complex, we use organisms with diverse lifespans – the worm C. elegans, the African killifis... |
Protéger et recycler : comment les cellules régulent la dormanceNos recherches visent à élucider comment la croissance et la division cellulaires sont régulées dans l'espace et dans le temps, notamment par la dégradation sélective des composants cellulaires. Les cellules eucaryotes utilisent l'autophagie et le système ubiquitine-protéasome (UPS) pour assurer ... |
Deconstruct-Reconstruct Decode cancer-immune crosstalk & probe with organoids.The Roose team at UCSF studies mechanisms of cell-cell interactions in immunology and cancer1-7, with emphasis on personalized medicine4,8 and single cell approaches9-11. Over the past 7 years, we shifted a large portion of our research efforts to understanding human biology and disease. We are d... |
How do single bacterial cells think?The functioning of genome-wide gene regulatory networks in bacteria presents us with an apparent paradox. On the one hand, bacterial populations successfully coordinate their gene expression patterns and phenotypes to allow them to grow in a huge variety of environments, including complex combina... |
Contrôle de la taille des cellulesLa taille des cellules joue un rôle crucial dans le fonctionnement de divers types de cellules dans tout le corps humain, influençant la structure des organites, la biosynthèse et les processus de transport en surface. Bien que certains gènes influençant la taille des cellules aient été identifié... |
Nucleosomes and DNA methylation implications for immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome and cancersDNA methylation is a broadly observed epigenetic modification. As genomic DNA methylation profiles dynamically change during development and aging, alterations in DNA methylation patterns are linked to diseases such as cancers and immunodeficiency. ICF syndrome is characterized by hypomethylation... |
Génome non-codantLe cours « NON-CODING GENOME » explorera la diversité des éléments d'ADN non géniques et des ARN non codants dans un large spectre de processus cellulaires, chez l'homme et les organismes modèles, ainsi que leur implication dans la physiologie et la pathologie. Des experts de renommée internation... |
Cutting and Pasting DNA to Create our Adaptive Immune SystemV(D)J recombination is essential for generating the adaptive immune response and unlimited number of different antibodies and antigen receptors. Encoded by multiple V, D and J gene segments, antigen receptors are assembled by programmed double-stranded DNA cleavage and imprecise re-joining. RAG1/... |
Bioengineering Human Embryo and Organ ModelsEarly human development remains mysterious and difficult to study. Recent advances in developmental biology, stem cell biology and bioengineering have contributed to a significant interest in constructing controllable, stem cell-based models of human embryo and organs (embryoids / organoids). T... |
Analyse spatiale de données multimodales : quand les omiques rencontrent les images (Biologie des Systèmes du Cancer)Le cours réunira des intervenants de premier plan issus de différents domaines de la biologie des systèmes cancéreux, de la recherche sur le cancer et de la clinique. Les orateurs invités exposeront diverses approches pour l'analyse et l'interprétation des données omiques, d'imagerie et cliniques... |
Endocytic control of cell plasticity in cancerOver the past two decades, there has been a significant shift in our understanding of the role of endocytosis and trafficking of signaling receptors. It has evolved from being viewed simply as a signal extinguisher (resulting in long-term attenuation) to being recognized as a sophisticated mechan... |